Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4

ABSTRACT: Human breast cancer cell line MCF-7 is usually sensitive to chemotherapy drug BMS-554417, an insulin receptor (IR) and insulin-like growth factor receptor (IGFR) inhibitor. However, through step-wise increase in BMS-554417 doses in culture media, we were able able to screen and select a single MCF-7 clone that is BMS-554417 resistant. It is cross resistant to BMS-536924. This new line of MCF-7 cells was named as MCF-7R4. The transcriptome profiling of both MCF-7 and MCF-7R4 was performed using Affymetrix HG-U133 plus2.0 GeneChip arrays. Five replicates of MCF-7 and five replicates of MCF-7R4 were profiled.

ORGANISM(S): Homo sapiens

SUBMITTER: Yan Asmann

PROVIDER: E-GEOD-18912 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924.

Hou Xiaonan X Huang Fei F Carboni Joan M JM Flatten Karen K Asmann Yan W YW Ten Eyck Cynthia C Nakanishi Takeo T Tibodeau Jennifer D JD Ross Douglas D DD Gottardis Marco M MM Erlichman Charles C Kaufmann Scott H SH Haluska Paul P

Molecular cancer therapeutics 20110101 1

Preclinical investigations have identified insulin-like growth factor (IGF) signaling as a key mechanism for cancer growth and resistance to clinically useful therapies in multiple tumor types including breast cancer. Thus, agents targeting and blocking IGF signaling have promise in the treatment of solid tumors. To identify possible mechanisms of resistance to blocking the IGF pathway, we generated a cell line that was resistant to the IGF-1R/InsR benzimidazole inhibitors, BMS-554417 and BMS-53 ...[more]

PMID: 21220496

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Dataset Information

Expression profiling of breast cancer cell lines MCF-7 and MCF-7R4

Publications

Drug efflux by breast cancer resistance protein is a mechanism of resistance to the benzimidazole insulin-like growth factor receptor/insulin receptor inhibitor, BMS-536924.

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