Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: xin wu
PROVIDER: E-GEOD-18914 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Wu Xin X Schmidt Jonathan A JA Avarbock Mary R MR Tobias John W JW Carlson Claire A CA Kolon Thomas F TF Ginsberg Jill P JP Brinster Ralph L RL
Proceedings of the National Academy of Sciences of the United States of America 20091214 51
In the human testis, beginning at approximately 2 months of age, gonocytes are replaced by adult dark (Ad) and pale (Ap) spermatogonia that make up the spermatogonial stem cell (SSC) pool. In mice, the SSC pool arises from gonocytes approximately 6 days after birth. During puberty in both species, complete spermatogenesis is established by cells that differentiate from SSCs. Essentially pure populations of prepubertal human spermatogonia and mouse gonocytes were selected from testis biopsies and ...[more]