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Human monocyte-derived dendritic cells: Control vs Tolerogenic

ABSTRACT: Transcriptional profiling of human dendritic cells (DC) comparing control (DC generated with GM-CSF plus IL-4) with three different treatments of tolerogenic (DC generated with GM-CSF plus IL-4 and IL-10, or IL-4, IL-10, and IL-6, or IL-4, IL-10, and TGF-b1) Three two-condition experiments, control (N) vs tolerogenic DC with three different treatments. Pool of 4 indivuduals for each condition. One replicate per array.

ORGANISM(S): Homo sapiens

SUBMITTER: Carmen SÃ¡nchez-Torres

PROVIDER: E-GEOD-18921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tolerogenic dendritic cells generated with different immunosuppressive cytokines induce antigen-specific anergy and regulatory properties in memory CD4+ T cells.

Torres-Aguilar Honorio H Aguilar-Ruiz Sergio R SR González-Pérez Gabriela G Munguía Rosario R Bajaña Sandra S Meraz-Ríos Marco A MA Sánchez-Torres Carmen C

Journal of immunology (Baltimore, Md. : 1950) 20100118 4

Dendritic cells (DCs) are professional APCs involved in the initiation of both immunity and immunological tolerance. In autoimmune diseases or graft rejections, most reactive lymphocytes are effector/memory cells. It is believed that memory T cells are more resistant to tolerance induction than naive lymphocytes; however, studies on mechanisms for their efficient tolerization are still scarce. In this study, we generated human monocyte-derived DCs by culture with GM-CSF and IL-4 (control DCs), a ...[more]

PMID: 20083662

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