Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Attila Szanto
PROVIDER: E-GEOD-29131 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kis-Toth Katalin K Szanto Attila A Thai To-Ha TH Tsokos George C GC
Journal of immunology (Baltimore, Md. : 1950) 20110627 3
Recent studies in cell lines and genetically engineered mice have demonstrated that cytosolic dsDNA could activate dendritic cells (DCs) to become effector APCs. Recognition of DNA might be a major factor in antimicrobial immune responses against cytosolic pathogens and also in human autoimmune diseases such as systemic lupus erythematosus. However, the role of cytosolic dsDNA in human DC activation and its effects on effector T and B cells are still elusive. In this study, we demonstrate that i ...[more]