Modulation of the transcriptional response to recombinant IFN-β by Acetaminophen
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ABSTRACT: We examined the effect of acetaminophen (APAP) on the transcriptional response induced by interferon-β (IFN-β). Transcript levels from total RNA isolated rom murine livers were determined using G4121B whole genome arrays. Keywords: Pharmakinetics, drug treatment 6-8 week male CD-1 mice were administered vehicle alone, APAP, IFN-β or IFN-β + APAP (n=5 per treatment per time point 40 animals total) and were euthanized at 1.5 or 4 hours post-treatment. Agilent 22k whole genome arrays were used to measure changes in mRNA transcripts in the liver mRNA. Stratatagene Universal Mouse RNA was used as a reference.
ORGANISM(S): Mus musculus
SUBMITTER: Aaron Farnsworth
PROVIDER: E-GEOD-18949 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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