Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Dong-Mi Shin
PROVIDER: E-GEOD-19162 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Suzuki Teruhiko T Kosaka-Suzuki Natsuki N Pack Svetlana S Shin Dong-Mi DM Yoon Jeongheon J Abdullaev Ziedulla Z Pugacheva Elena E Morse Herbert C HC Loukinov Dmitri D Lobanenkov Victor V
Molecular and cellular biology 20100315 10
Previously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. To develop an understanding of the functional activities of BORIS, we generated BORIS knockout (KO) mice. Mice homozygous for the null allele had a defect in spermatogenesis that resulted in small testes associated with increased cell death. The defect was evident as early as postnatal day 21 and was ...[more]