Expression profiling of IL6 and Myc TG mouse plasmacytoma
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Wendy DuBois
PROVIDER: E-GEOD-19336 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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Project description:To identify differentially expressed genes in mouse IL6 and Myc double TG plasmacytoma, total RNAs from mouse plasmacytoma generated from IL6 + Myc TG mice were applied to NIAID mouse gene expression arrays. The transcriptome in IL6+ Myc TG mouse PCT was compared to transcriptome in IL6 TG mouse PCT
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Project description:Expression profiling of IL6 and Myc TG mouse plasmacytoma
| PRJNA121705 | ENA
Project description:A hallmark feature of mature B cell tumors in humans is the occurrence of balanced chromosomal translocations, most often involving immunoglobulin (Ig) genes and a wide range of partner genes. Ig/oncogene translocations also occur in mice. However, they are regularly associated with a specific tumor type only for plasmacytomas (PCT), a neoplasm that features Ig/Myc translocations in over 95% of cases. In addition to the contribution of Myc signaling to mouse B cell lymphomagenesis, to identify any other oncogenic pathway in mouse PCT, expression profiling of mouse PCT was performed.
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