Transcription profiling of IFN-gamma transcriptional responses in control and IFN-gamma primed primary human macrophages
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Xiaoyu Hu
PROVIDER: E-GEOD-1925 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1.
Hu Xiaoyu X Park-Min Kyung-Hyun KH Ho Hao H HH Ivashkiv Lionel B LB
Journal of immunology (Baltimore, Md. : 1950) 20050901 6
Priming of macrophages with IFN-gamma increases cellular responsiveness to inflammatory stimuli, including IFN-gamma itself. We described previously that priming with subactivating concentrations of IFN-gamma increased Stat1 expression and resulted in enhanced activation of Stat1 and of a subset of IFN-gamma-responsive genes when primed macrophages were restimulated with low doses of IFN-gamma. In this study, we determined the effects of IFN-gamma priming on the macrophage transcriptome and on t ...[more]
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