Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Reba Condiotti
PROVIDER: E-GEOD-19306 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Molecular therapy : the journal of the American Society of Gene Therapy 20130828 1
Lentiviral vectors are widely used in basic research and clinical applications for gene transfer and long-term expression; however, safety issues have not yet been completely resolved. In this study, we characterized hepatocarcinomas that developed in mice 1 year after in utero administration of a feline-derived lentiviral vector. Mapped viral integration sites differed among tumors and did not coincide with the regions of chromosomal aberrations. Furthermore, gene expression profiling revealed ...[more]