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Adrenal gland gene expression from adult (12-week old) hypertensive BPH and adult (12-week old) hypotensive BPL mice

ABSTRACT: The objective of the experiment is to determine the genes differentially expressed in the adrenal gland of adult (12-week) BPH and BPL mice. Adrenal glands from adult (12-week) hypertensive BPH mice (n=3) and adult (12-week) hypotensive BPL mice (n=3).

ORGANISM(S): Mus musculus

SUBMITTER: Ryan Friese 

PROVIDER: E-GEOD-19342 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Neuroendocrine transcriptome in genetic hypertension: multiple changes in diverse adrenal physiological systems.

Fries Ryan S RS   Mahboubi Payam P   Mahapatra Nitish R NR   Mahata Sushil K SK   Schork Nicholas J NJ   Schmid-Schoenbein Geert W GW   O'Connor Daniel T DT  

Hypertension (Dallas, Tex. : 1979) 20040601 6

The genetic basis of hypertension in the genetically/hereditary hypertensive (BPH/2) mouse strain is incompletely understood, although a recent genome scan uncovered evidence for several susceptibility loci. To probe the neuroendocrine transcriptome in this disease model, 12 488 probe set microarray experiments were performed on mRNA transcripts from adrenal glands of juvenile (prehypertensive) and adult BPH/2 (hypertensive), as well as the genetically/hereditary low-blood pressure (BPL/1), stra  ...[more]

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