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Transcription profiling of dog lung samples after mechanical ventilation

ABSTRACT: This series contain unilateral mechanical ventilated canine lung samples.

ORGANISM(S): Canis familiaris

SUBMITTER: Shwu-Fan Ma

PROVIDER: E-GEOD-1935 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Microarray analysis of regional cellular responses to local mechanical stress in acute lung injury.

Simon Brett A BA Easley R Blaine RB Grigoryev Dmitry N DN Ma Shwu-Fan SF Ye Shui Q SQ Lavoie Tera T Tuder Rubin M RM Garcia Joe G N JG

American journal of physiology. Lung cellular and molecular physiology 20060616 5

Human acute lung injury is characterized by heterogeneous tissue involvement, leading to the potential for extremes of mechanical stress and tissue injury when mechanical ventilation, required to support critically ill patients, is employed. Our goal was to establish whether regional cellular responses to these disparate local mechanical conditions could be determined as a novel approach toward understanding the mechanism of development of ventilator-associated lung injury. We utilized cross-spe ...[more]

PMID: 16782753

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