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Transcription profiling of lung samples from mouse and rat treated with mechanical ventilation

ABSTRACT: This series contain mouse and rat lung samples treated with mechanical ventilation and corresponded controls.

ORGANISM(S): Mus musculus

SUBMITTER: Shwu-Fan Ma

PROVIDER: E-GEOD-2368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Bioinformatic identification of novel early stress response genes in rodent models of lung injury.

Ma Shwu-Fan SF Grigoryev Dmitry N DN Taylor Angela D AD Nonas Stephanie S Sammani Saad S Ye Shui Qing SQ Garcia Joe G N JG

American journal of physiology. Lung cellular and molecular physiology 20050520 3

Acute lung injury is a complex illness with a high mortality rate (>30%) and often requires the use of mechanical ventilatory support for respiratory failure. Mechanical ventilation can lead to clinical deterioration due to augmented lung injury in certain patients, suggesting the potential existence of genetic susceptibility to mechanical stretch (6, 48), the nature of which remains unclear. To identify genes affected by ventilator-induced lung injury (VILI), we utilized a bioinformatic-intense ...[more]

PMID: 15908477

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