Dataset Information
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Kate Schroder
PROVIDER: E-GEOD-19492 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Conservation and divergence in Toll-like receptor 4-regulated gene expression in primary human versus mouse macrophages.
Proceedings of the National Academy of Sciences of the United States of America 20120326 16
Evolutionary change in gene expression is generally considered to be a major driver of phenotypic differences between species. We investigated innate immune diversification by analyzing interspecies differences in the transcriptional responses of primary human and mouse macrophages to the Toll-like receptor (TLR)-4 agonist lipopolysaccharide (LPS). By using a custom platform permitting cross-species interrogation coupled with deep sequencing of mRNA 5' ends, we identified extensive divergence in ...[more]
