Unknown,Transcriptomics,Genomics,Proteomics

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DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

ABSTRACT: [original title] Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays. The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in the resulting cells using SuperArray Oligo GEArrayÂ® Human DNA Damage Signaling Pathway Microarray. HeLa cells were treated with fractionated 252Cf neutron and X-rays, with a cumulative dose of 75 Gy each, over 8 months, yielding the sub-lines HeLaNR and HeLaXR.Gene expression patterns of the radioresistant sub-lines were studied through microarray analysis

ORGANISM(S): Homo sapiens

SUBMITTER: yi qing

PROVIDER: E-GEOD-19526 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays.

Qing Yi Y Yang Xue-Qin XQ Zhong Zhao-Yang ZY Lei Xin X Xie Jia-Yin JY Li Meng-Xia MX Xiang De-Bing DB Li Zeng-Peng ZP Yang Zhen-Zhou ZZ Wang Ge G Wang Dong D

BMC cancer 20100225

<h4>Background</h4>The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in the resulting cells using microarray analysis of DNA damage repair genes.<h4>Methods</h4>HeLa cells were treated with fractionated 252Cf neutron and X-rays, with a cumulative dose of 75 Gy each, over 8 months, yielding the sub-lines HeLaNR and HeLaXR. Radioresistant ch ...[more]

PMID: 20184742

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Dataset Information

DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays

Publications

Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays.

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