Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jérome Rollin
PROVIDER: E-GEOD-19597 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Velasco Guillaume G Hubé Florent F Rollin Jérôme J Neuillet Damien D Philippe Cathy C Bouzinba-Segard Haniaa H Galvani Angélique A Viegas-Péquignot Evani E Francastel Claire C
Proceedings of the National Academy of Sciences of the United States of America 20100503 20
Methylation of cytosine residues within the CpG dinucleotide in mammalian cells is an important mediator of gene expression, genome stability, X-chromosome inactivation, genomic imprinting, chromatin structure, and embryonic development. The majority of CpG sites in mammalian cells is methylated in a nonrandom fashion, raising the question of how DNA methylation is distributed along the genome. Here, we focused on the functions of DNA methyltransferase-3b (Dnmt3b), of which deregulated activity ...[more]