Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis

ABSTRACT: The host antitumor immunity changes drastically during carcinogenesis. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. We found that the host antitumor immune reaction changes from an immune response to immune tolerance between intraductal papillary-mucinous adenoma (IPMA) and intraductal papillary-mucinous carcinoma (IPMC). In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages. We collected normal and neoplastic epithelial cells from frozen tissue sections (normal main pancreatic duct, IPMA, IPMC, and invasive carcinoma originating in IPMN) by laser microdissection, extracted total RNA from them, and analyzed their gene expression profiles using Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Nobuyoshi Hiraoka 

PROVIDER: E-GEOD-19650 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis.

Hiraoka Nobuyoshi N   Yamazaki-Itoh Rie R   Ino Yoshinori Y   Mizuguchi Yasunori Y   Yamada Tesshi T   Hirohashi Setsuo S   Kanai Yae Y  

Gastroenterology 20101016 1

<h4>Background & aims</h4>Anti-tumor immunity changes over the course of tumor progression; it is not clear how or when the developing tumor overcomes immune surveillance. Intraductal papillary mucinous neoplasm (IPMN) is an intraepithelial precursor lesion of pancreatic cancer that progresses from adenoma to carcinoma. We investigated when and how the human anti-tumor immune reaction changes during pancreatic tumor development.<h4>Methods</h4>Using immunohistochemical analysis of cells isolated  ...[more]

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