Transcriptomics

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Expression data from epithelial cells during the process of multistep pancreatic carcinogenesis


ABSTRACT: The host antitumor immunity changes drastically during carcinogenesis. Intraductal papillary-mucinous neoplasm (IPMN) of the pancreas is a precursor lesion of pancreatic cancer and progresses according to adenoma-carcinoma sequence. We found that the host antitumor immune reaction changes from an immune response to immune tolerance between intraductal papillary-mucinous adenoma (IPMA) and intraductal papillary-mucinous carcinoma (IPMC). In order to determine molecules affecting intraepithelial DC infiltration in IPMNs during multistep carcinogenesis, we examined the gene-expression profiles of entire transcripts of neoplastic cells at different stages.

ORGANISM(S): Homo sapiens

PROVIDER: GSE19650 | GEO | 2010/12/23

SECONDARY ACCESSION(S): PRJNA122545

REPOSITORIES: GEO

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