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Expression data from Th2 cell of ECM1 KO mice vs WT mice


ABSTRACT: CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during helper T cells differentiation. We used microarrays to clarify the global programme of gene expression difference underlying fully developed Th2 cells from WT and ECM1 KO mice and identified distinct classes of up and down regulated genes by ECM1. Naïve CD4+ T cells are seperated from WT and ECM1 mice, cultured and harveseted for RNA extraction and hybridization on Affymetrix microarrays.

ORGANISM(S): Mus musculus

SUBMITTER: Yuan Zhang 

PROVIDER: E-GEOD-19707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

ECM1 controls T(H)2 cell egress from lymph nodes through re-expression of S1P(1).

Li Zhenhu Z   Zhang Yuan Y   Liu Zhiduo Z   Wu Xiaodong X   Zheng Yuhan Y   Tao Zhiyun Z   Mao Kairui K   Wang Jie J   Lin Guomei G   Tian Lin L   Ji Yongyong Y   Qin Meiling M   Sun Shuhui S   Zhu Xueliang X   Sun Bing B  

Nature immunology 20110109 2


Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was as  ...[more]

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