Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Yuan Zhang
PROVIDER: E-GEOD-19707 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Li Zhenhu Z Zhang Yuan Y Liu Zhiduo Z Wu Xiaodong X Zheng Yuhan Y Tao Zhiyun Z Mao Kairui K Wang Jie J Lin Guomei G Tian Lin L Ji Yongyong Y Qin Meiling M Sun Shuhui S Zhu Xueliang X Sun Bing B
Nature immunology 20110109 2
Type 2 helper T cells (T(H)2) are critically involved in allergies and asthma. Here we demonstrate that extracellular matrix protein-1 (ECM1) is highly and selectively expressed in T(H)2 cells. ECM1 deficiency caused impaired T(H)2 responses and reduced allergic airway inflammation in vivo. Functional analysis demonstrated that although the T(H)2 polarization of ECM1-deficient cells was unimpaired, these cells had a defect in migration and were retained in peripheral lymphoid organs. This was as ...[more]