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Genes regulated by miR-145

ABSTRACT: We used Affymetrix HG U133 Plus 2.0 GeneChips to compare the transcriptome of miR-145-overexpressing MDA-MB-231 cells against negative control miRNA precursor-transfected cells. MDA-MB-231 cells were transfected with pre-miR-145 or a negative control pre-miRNA, and subsequently total RNA was collected and processed for analysis using Affymetrix microarrays. Three independent replicates were prepared for each comparison group.

ORGANISM(S): Homo sapiens

SUBMITTER: George Yip 

PROVIDER: E-GEOD-19737 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

miR-145-dependent targeting of junctional adhesion molecule A and modulation of fascin expression are associated with reduced breast cancer cell motility and invasiveness.

Götte M M   Mohr C C   Koo C-Y CY   Stock C C   Vaske A-K AK   Viola M M   Ibrahim S A SA   Peddibhotla S S   Teng Y H-F YH   Low J-Y JY   Ebnet K K   Kiesel L L   Yip G W GW  

Oncogene 20100906 50

Micro RNAs are small non-coding RNAs, which regulate fundamental cellular and developmental processes at the transcriptional and translational level. In breast cancer, miR-145 expression is downregulated compared with healthy control tissue. As several predicted targets of miR-145 potentially regulate cell motility, we aimed at investigating a potential role for miR-145 in breast cancer cell motility and invasiveness. Assisted by Affymetrix array technology, we demonstrate that overexpression of  ...[more]

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