P27 binds to promoters of multiple genes leading to their repression
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ABSTRACT: The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation. Crosslinked chromatin from quiescent NIH3T3 cells was sonicated, incubated overnight with the rabbit anti-p27 and IgG antibodies as control
ORGANISM(S): Mus musculus
SUBMITTER: oriol bachs
PROVIDER: E-GEOD-20068 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
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