Unknown,Transcriptomics,Genomics,Proteomics

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P27 binds to promoters of multiple genes leading to their repression


ABSTRACT: The role of the cyclin-cdk inhibitor p27 in tumorigenesis is still a controversial matter. We demonstrate here that p27 negatively regulates transcription of a number of genes (p27-target genes) involved in key cellular functions as RNA processing, translation, respiration and cell proliferation. Crosslinked chromatin from quiescent NIH3T3 cells was sonicated, incubated overnight with the rabbit anti-p27 and IgG antibodies as control

ORGANISM(S): Mus musculus

SUBMITTER: oriol bachs 

PROVIDER: E-GEOD-20068 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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