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Consequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet


ABSTRACT: Dietary proteins have profound effects on lipid metabolism but the mechanism remains to be elucidated. In the present study, we examined the temporal impact of dietary proteins in isoenergetic high fat diets on lipid metabolism of C57BL/6J mice. Mice were first fed a low protein (P) to carbohydrate (C) ratio high-fat diet (L-P/C-HF) for 10 weeks and then a half of mice were changed to a high protein to carbohydrate ratio high-fat diet (H-P/C-HF) for additional 4 weeks whereas the remaining mice continued eating the L-P/C-HF diet.

ORGANISM(S): Mus musculus

SUBMITTER: Frederic Raymond 

PROVIDER: E-GEOD-20260 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Consequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet.

Raymond Frédéric F   Wang Long L   Moser Mireille M   Metairon Sylviane S   Mansourian Robert R   Zwahlen Marie-Camille MC   Kussmann Martin M   Fuerholz Andreas A   Macé Katherine K   Chou Chieh Jason CJ  

PloS one 20121106 11


Consumption of low-carbohydrate, high-protein, high-fat diets lead to rapid weight loss but the cardioprotective effects of these diets have been questioned. We examined the impact of high-protein and high-fat diets on cholesterol metabolism by comparing the plasma cholesterol and the expression of cholesterol biosynthesis genes in the liver of mice fed a high-fat (HF) diet that has a high (H) or a low (L) protein-to-carbohydrate (P/C) ratio. H-P/C-HF feeding, compared with L-P/C-HF feeding, dec  ...[more]

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