Comparison of normal mouse hematopoietic stem cells (HSC) to mobilized and leukemia-inducing hematopoietic stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Susan Prohaska
PROVIDER: E-GEOD-20359 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.
Forsberg E Camilla EC Passegué Emmanuelle E Prohaska Susan S SS Wagers Amy J AJ Koeva Martina M Stuart Joshua M JM Weissman Irving L IL
PloS one 20100120 1
Hematopoietic stem cells (HSC) are rare, multipotent cells capable of generating all specialized cells of the blood system. Appropriate regulation of HSC quiescence is thought to be crucial to maintain their lifelong function; however, the molecular pathways controlling stem cell quiescence remain poorly characterized. Likewise, the molecular events driving leukemogenesis remain elusive. In this study, we compare the gene expression profiles of steady-state bone marrow HSC to non-self-renewing m ...[more]
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