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T cell genes regulated by retinoic acid

ABSTRACT: This is to determine the T cell genes regulated by retinoic acid. 3 groups of CD4+ T cells (control, RA and Ro) 2 arrays were used for each group

ORGANISM(S): Mus musculus

SUBMITTER: chang Kim

PROVIDER: E-GEOD-20500 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Complementary roles of retinoic acid and TGF-β1 in coordinated expression of mucosal integrins by T cells.

Kang S G SG Park J J Cho J Y JY Ulrich B B Kim C H CH

Mucosal immunology 20100721 1

α(4) and β(7) integrins, such as α(4)β(1), α(4)β(7), and α(E)β(7), are major integrins required for migration of leukocytes into mucosal tissues. The mechanisms responsible for coordinated expression of these three integrins have been poorly elucidated to date. We report that expression of the Itg-α(4) subunit by both CD4(+) and CD8(+) T cells requires the retinoic acid signal. In contrast, transcription of Itg-α(E) genes is induced by the transforming growth factor-β1 (TGFβ1) signal. Expression ...[more]

PMID: 20664575

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