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Human nephrosclerosis triggers a hypoxia-related glomerulopathy.

ABSTRACT: Expression data from microdissected glomeruli to examine the role of hypoxia in glomerulosclerosis of human Nephrosclerosis (NSC). Human Kidney biopsies of patients with NSC (n=14) and TN (n=4) were selected for RNA extraction and hybridization on Affymetrix microarrays. Gene expression data was then analysed using Genepattern and Genomatix software suites which revealed that CXCR4/CXCL12 plays a role in human NSC and therefore indicate that hypoxia contributes to glomerular damage in NSC. This dataset is part of the TransQST collection.

ORGANISM(S): Homo sapiens

SUBMITTER: Preethi Sankaranarayanan

PROVIDER: E-GEOD-20602 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Human nephrosclerosis triggers a hypoxia-related glomerulopathy.

Neusser Matthias A MA Lindenmeyer Maja T MT Moll Anton G AG Segerer Stephan S Edenhofer Ilka I Sen Kontheari K Stiehl Daniel P DP Kretzler Matthias M Gröne Hermann-Josef HJ Schlöndorff Detlef D Cohen Clemens D CD

The American journal of pathology 20091217 2

In the kidney, hypoxia contributes to tubulointerstitial fibrosis, but little is known about its implications for glomerular damage and glomerulosclerosis. Chronic hypoxia was hypothesized to be involved in nephrosclerosis (NSC) or "hypertensive nephropathy." In the present study genome-wide expression data from microdissected glomeruli were studied to examine the role of hypoxia in glomerulosclerosis of human NSC. Functional annotation analysis revealed prominent regulation of hypoxia-associate ...[more]

PMID: 20019191

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