Unknown,Transcriptomics,Genomics,Proteomics

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Genome-wide expression profiles of primary human SAECs infected with different adenovirus mutants.


ABSTRACT: Full title: Genome-wide expression profiles of primary human small airway epithelial cells (SAECs) infected with different adenovirus mutants. Expression arrays were used to analyze global gene expression changes in SAECs infected with either mock, dE1B-55k, or d55k/dORF3 adenovirus at 36 hours post infection, as well as nutlin treatment for 12 hours. Two independent experiments were performed with each experimental condition done in duplicate. CEL files were imported and analyzed with Partek Analysis software.

ORGANISM(S): Homo sapiens

SUBMITTER: Conrado Soria 

PROVIDER: E-GEOD-20607 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Heterochromatin silencing of p53 target genes by a small viral protein.

Soria Conrado C   Estermann Fanny E FE   Espantman Kristen C KC   O'Shea Clodagh C CC  

Nature 20100801 7310


The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response to oncogenes and DNA damage. During adenovirus replication, the degradation of p53 by E1B-55k is considered essential for p53 inactivation, and is the basis for p53-selective viral cancer therapies. Here we reveal a dominant epigenetic mechanism that  ...[more]

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