Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Conrado Soria
PROVIDER: E-GEOD-20607 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Soria Conrado C Estermann Fanny E FE Espantman Kristen C KC O'Shea Clodagh C CC
Nature 20100801 7310
The transcription factor p53 (also known as TP53) guards against tumour and virus replication and is inactivated in almost all cancers. p53-activated transcription of target genes is thought to be synonymous with the stabilization of p53 in response to oncogenes and DNA damage. During adenovirus replication, the degradation of p53 by E1B-55k is considered essential for p53 inactivation, and is the basis for p53-selective viral cancer therapies. Here we reveal a dominant epigenetic mechanism that ...[more]