Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Fredy Siegrist
PROVIDER: E-GEOD-20693 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cortázar Daniel D Kunz Christophe C Selfridge Jim J Lettieri Teresa T Saito Yusuke Y MacDougall Eilidh E Wirz Annika A Schuermann David D Jacobs Angelika L AL Siegrist Fredy F Steinacher Roland R Jiricny Josef J Bird Adrian A Schär Primo P
Nature 20110130 7334
Thymine DNA glycosylase (TDG) is a member of the uracil DNA glycosylase (UDG) superfamily of DNA repair enzymes. Owing to its ability to excise thymine when mispaired with guanine, it was proposed to act against the mutability of 5-methylcytosine (5-mC) deamination in mammalian DNA. However, TDG was also found to interact with transcription factors, histone acetyltransferases and de novo DNA methyltransferases, and it has been associated with DNA demethylation in gene promoters following activat ...[more]