Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases

ABSTRACT: Gene expression profiling (GEP) can reveal characteristic signatures associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed GEP on Down syndrome (DS) and comparison non-Down syndrome (NDS) ALL cases to identify biologic differences between these groups. Ficoll-enriched, cryopreserved diagnostic bone marrow samples were obtained from patients with newly diagnosed B-precursor acute lymphoblastic leukemia.

ORGANISM(S): Homo sapiens

SUBMITTER: Hon-chiu Leung 

PROVIDER: E-GEOD-20910 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles.

Loudin M G MG   Wang J J   Leung H-C Eastwood HC   Gurusiddappa S S   Meyer J J   Condos G G   Morrison D D   Tsimelzon A A   Devidas M M   Heerema N A NA   Carroll A J AJ   Plon S E SE   Hunger S P SP   Basso G G   Pession A A   Bhojwani D D   Carroll W L WL   Rabin K R KR  

Leukemia 20110607 10

Patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have distinct clinical and biological features. Whereas most DS-ALL cases lack the sentinel cytogenetic lesions that guide risk assignment in childhood ALL, JAK2 mutations and CRLF2 overexpression are highly enriched. To further characterize the unique biology of DS-ALL, we performed genome-wide profiling of 58 DS-ALL and 68 non-DS (NDS) ALL cases by DNA copy number, loss of heterozygosity, gene expression and methylation an  ...[more]

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