Dataset Information
Short-term (12h) ATRA treatment of embryoid bodies.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Zoltan Simandi
PROVIDER: E-GEOD-20919 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Activation of retinoic acid receptor signaling coordinates lineage commitment of spontaneously differentiating mouse embryonic stem cells in embryoid bodies.
FEBS letters 20100602 14
Retinoid signaling has been implicated in embryonic stem cell differentiation. Here we present a systematic analysis of gene expression changes in mouse embryonic stem cells (mESCs), during their spontaneous differentiation into embryoid bodies and the effect of all-trans retinoic acid (ATRA) on this process. We show that retinoic acid is present in the serum and is sufficient to activate retinoid signaling at a basal level in undifferentiated mESCs. This signal disappears during embryoid body f ...[more]
