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Transcription profiling of human adipose tissue using an expanded patient cohort

ABSTRACT: Obesity is a risk factor for numerous metabolic disorders; however, not all obese individuals are prone to insulin resistance. The central aim of this study was to identify molecular pathways directly related to insulin resistance independent of BMI in obesity. We sought to determine the gene expression signature of adipose tissue in a body mass index (BMI)-matched obese cohort of patients that are either insulin sensitive or insulin resistant. We determined the global gene expression signatures of omental and subcutaneous adipose tissue samples obtained from insulin-sensitive obese and insulin-resistant obese patients undergoing gastric bypass surgery. The SQ sample for Insulin Resistant Patient 6 has been removed from the study.

ORGANISM(S): Homo sapiens

SUBMITTER: Olga Theresa Hardy

PROVIDER: E-GEOD-20950 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Body mass index-independent inflammation in omental adipose tissue associated with insulin resistance in morbid obesity.

Hardy Olga T OT Perugini Richard A RA Nicoloro Sarah M SM Gallagher-Dorval Karen K Puri Vishwajeet V Straubhaar Juerg J Czech Michael P MP

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery 20100601 1

<h4>Background</h4>Obesity is a strong risk factor for resistance to insulin-mediated glucose disposal, a precursor of type 2 diabetes and other disorders. However, not all obese individuals are insulin resistant. We sought to identify the molecular pathways that might cause obesity-associated insulin resistance in humans by studying the morbidly obese who were insulin sensitive versus insulin resistant, thereby eliminating obesity as a variable.<h4>Methods</h4>Combining gene expression profilin ...[more]

PMID: 20678967

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