Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Takuya Miyakawa
PROVIDER: E-GEOD-21189 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hiona Asimina A Sanz Alberto A Kujoth Gregory C GC Pamplona Reinald R Seo Arnold Y AY Hofer Tim T Someya Shinichi S Miyakawa Takuya T Nakayama Chie C Samhan-Arias Alejandro K AK Servais Stephane S Barger Jamie L JL Portero-Otín Manuel M Tanokura Masaru M Prolla Tomas A TA Leeuwenburgh Christiaan C
PloS one 20100707 7
<h4>Background</h4>Aging results in a progressive loss of skeletal muscle, a condition known as sarcopenia. Mitochondrial DNA (mtDNA) mutations accumulate with aging in skeletal muscle and correlate with muscle loss, although no causal relationship has been established.<h4>Methodology/principal findings</h4>We investigated the relationship between mtDNA mutations and sarcopenia at the gene expression and biochemical levels using a mouse model that expresses a proofreading-deficient version (D257 ...[more]