Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Drosophila melanogaster mutation accumulation lines

ABSTRACT: Experiment to estimate mutatational variance of gene expression in Drosophila melanogaster at two times in development using 12 mutation accumulation lines. Keywords = evolution Keywords = quantitative genetics Keywords = Drosophila Keywords = mutation Each of 12 lines measured 8 times in each of two stages. For each stage, the design has two hexagons with 6 interior connections (=hybridizations) (all except opposite nodes). Each line in one hexagon is connected to one line in the other hexagon and that line's opposite. Each line is also connected to itself twice in the other stage. Dyes are balanced.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Scott Rifkin

PROVIDER: E-GEOD-2126 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression.

Rifkin Scott A SA Houle David D Kim Junhyong J White Kevin P KP

Nature 20051101 7065

Mutation is the ultimate source of biological diversity because it generates the variation that fuels evolution. Gene expression is the first step by which an organism translates genetic information into developmental change. Here we estimate the rate at which mutation produces new variation in gene expression by measuring transcript abundances across the genome during the onset of metamorphosis in 12 initially identical Drosophila melanogaster lines that independently accumulated mutations for ...[more]

PMID: 16281035

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Dataset Information

Drosophila melanogaster mutation accumulation lines

Publications

A mutation accumulation assay reveals a broad capacity for rapid evolution of gene expression.

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