Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Maria Figueroa
PROVIDER: E-GEOD-21273 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shah Mrinal Y MY Vasanthakumar Aparna A Barnes Natalie Y NY Figueroa Maria E ME Kamp Anna A Hendrick Christopher C Ostler Kelly R KR Davis Elizabeth M EM Lin Shang S Anastasi John J Le Beau Michelle M MM Moskowitz Ivan P IP Melnick Ari A Pytel Peter P Godley Lucy A LA
Cancer research 20100629 14
Epigenetic changes are among the most common alterations observed in cancer cells, yet the mechanism by which cancer cells acquire and maintain abnormal DNA methylation patterns is not understood. Cancer cells have an altered distribution of DNA methylation and express aberrant DNA methyltransferase 3B transcripts, which encode truncated proteins, some of which lack the COOH-terminal catalytic domain. To test if a truncated DNMT3B isoform disrupts DNA methylation in vivo, we constructed two line ...[more]