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Transcription profiling of mouse fetal thymic organ culture BDC2.5 CD4+CD8+ thymocytes from B6g7 or NOD strain backgrounds following addition of the BDC mimotope peptide

ABSTRACT: Fetal thymic organ culture (FTOC) DC2.5 CD4+CD8+ thymocytes from B6g7 or NOD background. 0 or 16 hour after addition of the BDC mimitope

ORGANISM(S): Mus musculus

SUBMITTER: CBDM Lab

PROVIDER: E-GEOD-2128 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Defective central tolerance induction in NOD mice: genomics and genetics.

Zucchelli Silvia S Holler Phil P Yamagata Tetsuya T Roy Matthew M Benoist Christophe C Mathis Diane D

Immunity 20050301 3

The genetic determinism of type-1 diabetes in NOD mice likely involves complementary defects in central T cell tolerance induction and peripheral immunoregulation. To study the contribution of the NOD genetic background to central tolerance, we followed the behavior of BDC2.5 clonotype thymocytes in fetal thymic organ cultures (FTOC). The NOD genetic background encodes a quantitative deficiency in the ability to delete these self-reactive thymocytes and to divert them to the CD8alphaalpha lineag ...[more]

PMID: 15780994

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