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Effect of Growth hormone on podocytes


ABSTRACT: Transcriptome analysis of growth hormone dependant genes in glomerular podocytes Differentiated human glomerular podocytes in culture exposed to growth hormone for 0 min, 2 min, 5 min, 15 min, and 30 min. Total RNA is extracted and subjected to microarray analysis.

ORGANISM(S): Homo sapiens

SUBMITTER: Ram Menon 

PROVIDER: E-GEOD-21327 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Growth hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: a novel action of gh with implications for the pathogenesis of diabetic nephropathy.

Kumar P Anil PA   Kotlyarevska Kateryna K   Dejkhmaron Prapai P   Reddy Gaddameedi R GR   Lu Chunxia C   Bhojani Mahaveer S MS   Menon Ram K RK  

The Journal of biological chemistry 20100803 41


Growth hormone (GH) excess results in structural and functional changes in the kidney and is implicated as a causative factor in the development of diabetic nephropathy (DN). Glomerular podocytes are the major barrier to the filtration of serum proteins, and altered podocyte function and/or reduced podocyte number is a key event in the pathogenesis of DN. We have previously shown that podocytes are a target for GH action. To elucidate the molecular basis for the effects of GH on the podocyte, we  ...[more]

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