Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Ram Menon
PROVIDER: E-GEOD-21327 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kumar P Anil PA Kotlyarevska Kateryna K Dejkhmaron Prapai P Reddy Gaddameedi R GR Lu Chunxia C Bhojani Mahaveer S MS Menon Ram K RK
The Journal of biological chemistry 20100803 41
Growth hormone (GH) excess results in structural and functional changes in the kidney and is implicated as a causative factor in the development of diabetic nephropathy (DN). Glomerular podocytes are the major barrier to the filtration of serum proteins, and altered podocyte function and/or reduced podocyte number is a key event in the pathogenesis of DN. We have previously shown that podocytes are a target for GH action. To elucidate the molecular basis for the effects of GH on the podocyte, we ...[more]