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SCGB3A2 suppresses bleomycin-induced pulmonary fibrosis through activation of STAT1 and up-regulation of SMAD7

ABSTRACT: We report for the first time that secretoglobin (SCGB) 3A2, a novel cytokine-like molecule, predominantly expressed in pulmonary airways epithelium, drastically reduced the severity of lung fibrosis using bleomycin-induced mouse model. DNA microarrays were performed using RNAs isolated from mouse lungs in two experiments. In the first experiments, mice were adminitered intravenously SCGB3A2 or PBS once daily for a week, starting on day 14 after BLM administration, and in the second experiments, SCGB3A2 or PBS was administered intravenously for 12 hrs.

ORGANISM(S): Mus musculus

SUBMITTER: Reiko Kurotani

PROVIDER: E-GEOD-21560 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Secretoglobin 3A2 suppresses bleomycin-induced pulmonary fibrosis by transforming growth factor beta signaling down-regulation.

Kurotani Reiko R Okumura Satoshi S Matsubara Tsutomu T Yokoyama Utako U Buckley John R JR Tomita Takeshi T Kezuka Kyohei K Nagano Tomokazu T Esposito Dominic D Taylor Troy E TE Gillette William K WK Ishikawa Yoshihiro Y Abe Hiroyuki H Ward Jerrold M JM Kimura Shioko S

The Journal of biological chemistry 20110410 22

With increasing worldwide rates of morbidity and mortality of pulmonary fibrosis, the development of effective therapeutics for this disease is of great interest. Secretoglobin (SCGB) 3A2, a novel cytokine-like molecule predominantly expressed in pulmonary airways epithelium, exhibits anti-inflammatory and growth factor activities. In the current study SCGB3A2 was found to inhibit TGFβ-induced differentiation of fibroblasts to myofibroblasts, a hallmark of the fibrogenic process, using pulmonary ...[more]

PMID: 21478551

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