Unknown,Transcriptomics,Genomics,Proteomics

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High Mobility Group protein HMGB2 is a Critical Regulator of Plasmodium Oocyst Development


ABSTRACT: Two mice per group were infected with one million purified schizonts from the WT and two clones (B3 and D1) of the pyhmgb2 KO lines. Parasitemia reached 10 to 20 % and equivalent gametocytemia total RNA was extracted from the WT and the B3 and D1 clones of the KO parasite lines using the Trizol method on saponin lysed of parasites. Four samples analysed including dye-swap

ORGANISM(S): Plasmodium yoelii

SUBMITTER: Mathieu Gissot 

PROVIDER: E-GEOD-9952 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

High mobility group protein HMGB2 is a critical regulator of plasmodium oocyst development.

Gissot Mathieu M   Ting Li-Min LM   Daly Thomas M TM   Bergman Lawrence W LW   Sinnis Photini P   Kim Kami K  

The Journal of biological chemistry 20080408 25


The sexual cycle of Plasmodium is required for transmission of malaria from mosquitoes to mammals, but how parasites induce the expression of genes required for the sexual stages is not known. We disrupted the Plasmodium yoelii gene encoding high mobility group nuclear factor hmgb2, which encodes a DNA-binding protein potentially implicated in transcriptional regulation of malaria gene expression. We investigated its function in vivo in the vertebrate and invertebrate hosts. Deltapyhmgb2 parasit  ...[more]

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