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Cell-Type-Specific TGF-beta Signaling is Targeted to Genes that Control Cell Identity

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Richard Young

PROVIDER: E-GEOD-21621 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Master transcription factors determine cell-type-specific responses to TGF-β signaling.

Mullen Alan C AC Orlando David A DA Newman Jamie J JJ Lovén Jakob J Kumar Roshan M RM Bilodeau Steve S Reddy Jessica J Guenther Matthew G MG DeKoter Rodney P RP Young Richard A RA

Cell 20111001 3

Transforming growth factor beta (TGF-β) signaling, mediated through the transcription factors Smad2 and Smad3 (Smad2/3), directs different responses in different cell types. Here we report that Smad3 co-occupies the genome with cell-type-specific master transcription factors. Thus, Smad3 occupies the genome with Oct4 in embryonic stem cells (ESCs), Myod1 in myotubes, and PU.1 in pro-B cells. We find that these master transcription factors are required for Smad3 occupancy and that TGF-β signaling ...[more]

PMID: 22036565

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