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Transcription profiling of human pediatric acute myeloid leukemia samples

ABSTRACT: This series represents leukemic samples obtained from pediatric AML patients at diagnosis and control normal bone marrow samples.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Hitoshi Ichikawa

PROVIDER: E-GEOD-2191 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Identification of a gene expression signature associated with pediatric AML prognosis.

Yagi Tomohito T Morimoto Akira A Eguchi Mariko M Hibi Shigeyoshi S Sako Masahiro M Ishii Eiichi E Mizutani Shuki S Imashuku Shinsaku S Ohki Misao M Ichikawa Hitoshi H

Blood 20030508 5

Most patients with acute myeloid leukemia (AML) enter complete remission (CR) after treatment with chemotherapy, but a large number of them experience relapse with resistant disease. To identify genes that are associated with their prognoses, we analyzed gene expression in 54 pediatric patients with AML using an oligonucleotide microarray that contained 12 566 probe sets. A supervised approach using the Student t test selected a prognostic set of 35 genes, some of which are associated with the r ...[more]

PMID: 12738660

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