Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sandeep Wontakal
PROVIDER: E-GEOD-21949 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
PLoS genetics 20110609 6
PU.1 is a hematopoietic transcription factor that is required for the development of myeloid and B cells. PU.1 is also expressed in erythroid progenitors, where it blocks erythroid differentiation by binding to and inhibiting the main erythroid promoting factor, GATA-1. However, other mechanisms by which PU.1 affects the fate of erythroid progenitors have not been thoroughly explored. Here, we used ChIP-Seq analysis for PU.1 and gene expression profiling in erythroid cells to show that PU.1 regu ...[more]