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Trichuris secretome - proteome data analysis

ABSTRACT: We analysed the excretory/secretory (ES) products and the exosomes secreted by the nematode Trichuris muris. Two batches of ES and Optiprep fractions of exosomes were analysed using a 5600+ mass spectrometer

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Trichuris Muris

SUBMITTER: Javier Sotillo

LAB HEAD: Alex Loukas

PROVIDER: PXD006344 | Pride | 2017-05-23

REPOSITORIES: Pride

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			Action	DRS
	1.mgf	Mgf
	10.mgf	Mgf
	11.mgf	Mgf
	12.mgf	Mgf
	13.mgf	Mgf

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Publications

Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host-parasite communication.

Eichenberger Ramon M RM Talukder Md Hasanuzzaman MH Field Matthew A MA Wangchuk Phurpa P Giacomin Paul P Loukas Alex A Sotillo Javier J

Journal of extracellular vesicles 20180121 1

Whipworms are parasitic nematodes that live in the gut of more than 500 million people worldwide. Owing to the difficulty in obtaining parasite material, the mouse whipworm Trichuris muris has been extensively used as a model to study human whipworm infections. These nematodes secrete a multitude of compounds that interact with host tissues where they orchestrate a parasitic existence. Herein we provide the first comprehensive characterization of the excretory/secretory products of T. ...[more]

PMID: 29410780

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Extracellular vesicles Trichuris muris

Project description:We analysed the exosomes secreted by the nematode Trichuris muris. Two replicates of exosomes were analysed using a 5600+ mass spectrometer

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Nematode ascarosides attenuate mammalian type 2 inflammatory responses

Project description:Mounting evidence suggests that helminthic infection can protect against disorders of immune dysregulation. Administration of live parasites or their excretory/secretory products (ES) has shown therapeutic effects across a wide range of animal models for immune disorders including asthma. Human clinical trials of live parasite ingestion for the treatment of immune disorders have produced promising results, yet concerns persist regarding ingestion of pathogenic organisms and unpredictable immune responses towards their protein components. Despite extensive efforts toward defining active components of ES, no small molecules with immune regulatory activity have been identified from nematodes. OBJECTIVE: Here we have aimed to identify the effect of evolutionarily conserved family of nematode pheromones called ascaroside, which is a small molecule produced by several animal parasitic nematode species, on pulmonary immune response and asthma severity in mice.

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Haemonchus contortus secretome LC-MS/MS

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Analysis of influence of Excretory Secretory Products from wild and laboratory Fasciola hepatica isolates on bovine macrophages

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Analysis of influence of Excretory Secretory Products from wild and laboratory Fasciola hepatica isolates on LPS activated bovine macrophages

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