Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Myelodysplastic/myeloproliferative neoplasms


ABSTRACT: This SuperSeries is composed of the following subset Series: GSE21948: High Density custom Agilent 44K CGH array analysis of 7q and TET2 region in myelodysplastic/myeloproliferative neoplasms GSE21990: Affymetrix SNP 6.0 array data for myelodysplastic/myeloproliferative neoplasms Refer to individual Series

ORGANISM(S): Homo sapiens

SUBMITTER: Andy Chase 

PROVIDER: E-GEOD-21991 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications


Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disorders revealed 49 monoallelic or biallelic EZH2 mutations in 42 individuals; the mutations were found most commonly in those with myelodysplastic/myeloproliferative neoplasms (27 out of 219 individuals,  ...[more]

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