Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andy Chase
PROVIDER: E-GEOD-21991 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Ernst Thomas T Chase Andrew J AJ Score Joannah J Hidalgo-Curtis Claire E CE Bryant Catherine C Jones Amy V AV Waghorn Katherine K Zoi Katerina K Ross Fiona M FM Reiter Andreas A Hochhaus Andreas A Drexler Hans G HG Duncombe Andrew A Cervantes Francisco F Oscier David D Boultwood Jacqueline J Grand Francis H FH Cross Nicholas C P NC
Nature genetics 20100704 8
Abnormalities of chromosome 7q are common in myeloid malignancies, but no specific target genes have yet been identified. Here, we describe the finding of homozygous EZH2 mutations in 9 of 12 individuals with 7q acquired uniparental disomy. Screening of a total of 614 individuals with myeloid disorders revealed 49 monoallelic or biallelic EZH2 mutations in 42 individuals; the mutations were found most commonly in those with myelodysplastic/myeloproliferative neoplasms (27 out of 219 individuals, ...[more]