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Genome-wide expression in the hippocampus of dab1 homozygous mutants in C57BL/6 and BALB/c mice.

ABSTRACT: Differential gene expression in the hippocampus was analyzed between Dab1 and wild type mice on the C57BL/6 and BALB/c mouse strains. Total RNA obtained from isolated hippocampus at postnatal day 19 was analysed for gene expression between C57BL6 and BALB/c wild type or dab1 mutant mice. Three samples from separate mice were analyzed from each genotype and strain.

ORGANISM(S): Mus musculus

SUBMITTER: Tohru Matsuki 

PROVIDER: E-GEOD-22044 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of Stk25 as a genetic modifier of Tau phosphorylation in Dab1-mutant mice.

Matsuki Tohru T   Zaka Mariam M   Guerreiro Rita R   van der Brug Marcel P MP   Cooper Jonathan A JA   Cookson Mark R MR   Hardy John A JA   Howell Brian W BW  

PloS one 20120215 2

Hyperphosphorylation of the microtubule binding protein Tau is a feature of a number of neurodegenerative diseases, including Alzheimer's disease. Tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however, it has not been clear if the Tau phosphorylation phenotype is a secondary effect of the morbidity of these mutants. The dab1 gene encodes a docking protein that is required for normal brain lamination and dendritogenesis as part of the Reelin signali  ...[more]

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