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Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis

ABSTRACT: Characterize the gpm1 mutant growth on dual substrate of ethanol and glycerol We used microarrays to detail the responses of the gpm1 mutant compare with reference

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Intawat Nookaew

PROVIDER: E-GEOD-22122 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis.

Papini Marta M Nookaew Intawat I Scalcinati Gionata G Siewers Verena V Nielsen Jens J

Biotechnology journal 20101001 10

The yeast Saccharomyces cerevisiae is able to adapt its metabolism to grow on different carbon sources and to shift to non-fermentative growth on C2 or C3 carbon sources (ethanol, acetate, or glycerol) through the activation of gluconeogenesis. Here, we studied the response to the deletion of the glycolytic and gluconeogenic gene GPM1, encoding for phosphoglycerate mutase. It was previously shown that a S. cerevisiae strain with non-functional copies of GPM1 can only grow when glycerol and ethan ...[more]

PMID: 20815084

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Phosphoglycerate mutase knock-out mutant Saccharomyces cerevisiae: physiological investigation and transcriptome analysis

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