Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Gene expression and genotype in normal heart

ABSTRACT: Genome-wide association studies have identified a small region at chromosome 9p21.3 strongly associated with coronary heart disease risk. The region contains no protein-coding genes and the mechanism underlying its association with heart disease is unknown. We investigated associations between rs1333049, a single nucleotide polymorphism representing the 9p21.3 locus, and levels of cardiac gene expression in myocardial tissue from donors with no documented history of heart disease. Individual myocardial gene expression profiles were generated with Affymetrix Human Gene 1.0 ST arrays (n=108). DNA genotyping was performed with Taqman assays. Associations between genotype and gene expression were analyzed assuming a recessive effect.

ORGANISM(S): Homo sapiens

SUBMITTER: Anna Pilbrow

PROVIDER: E-GEOD-22253 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.

Pilbrow Anna P AP Folkersen Lasse L Pearson John F JF Brown Chris M CM McNoe Les L Wang Nancy M NM Sweet Wendy E WE Tang W H Wilson WH Black Michael A MA Troughton Richard W RW Richards A Mark AM Franco-Cereceda Anders A Gabrielsen Anders A Eriksson Per P Moravec Christine S CS Cameron Vicky A VA

PloS one 20120629 6

Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at 9p21.3, the nearest genes being CDKN2A and CDKN2B. To understand the pathways by which this locus might influence CAD susceptibility, we investigated associations between the 9p21.3 risk genotype and global gene expression in heart tissue from donors with no diagnosed heart disease (n = 108, predominant cause of death, cerebral vascular accident) and in carotid plaque (n = 106), a ...[more]

PMID: 22768093

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Dataset Information

Gene expression and genotype in normal heart

Publications

The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.

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