Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jesus Osada
PROVIDER: E-GEOD-22310 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nuño-Ayala Mario M Guillén Natalia N Arnal Carmen C Lou-Bonafonte José M JM de Martino Alba A García-de-Jalón Jose-Antonio JA Gascón Sonia S Osaba Lourdes L Osada Jesús J Navarro María-Angeles MA
Physiological genomics 20120522 14
Hyperhomocysteinemia has been reported in human reproduction as a risk factor for early pregnancy loss, preeclampsia, and congenital birth defects like spina bifida. Female infertility was also observed in cystathionine beta synthase-deficient mice (Cbs-KO) as an animal model for severe hyperhomocysteinemia. The aim for the present research was to elucidate the time-point of pregnancy loss and to pinpoint gene and cellular changes involved in the underlying pathological mechanism. By mating 90-d ...[more]