Ontology highlight
ABSTRACT:
ORGANISM(S): Saccharomyces cerevisiae
SUBMITTER: Michael Shapira
PROVIDER: E-GEOD-2239 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Shapira Michael M Segal Eran E Botstein David D
Molecular biology of the cell 20040915 12
The effects of oxidative stress on yeast cell cycle depend on the stress-exerting agent. We studied the effects of two oxidative stress agents, hydrogen peroxide (HP) and the superoxide-generating agent menadione (MD). We found that two small coexpressed groups of genes regulated by the Mcm1-Fkh2-Ndd1 transcription regulatory complex are sufficient to account for the difference in the effects of HP and MD on the progress of the cell cycle, namely, G1 arrest with MD and an S phase delay followed ...[more]