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Transcription profiling of mouse autograft and allograft samples from femur

ABSTRACT: Comparison of autograft and allograft samples from C57Bl/6 femur

ORGANISM(S): Mus musculus

SUBMITTER: Andrew Brooks

PROVIDER: E-GEOD-2249 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy.

Ito Hiromu H Koefoed Mette M Tiyapatanaputi Prarop P Gromov Kirill K Goater J Jeffrey JJ Carmouche Jonathan J Zhang Xinping X Rubery Paul T PT Rabinowitz Joseph J Samulski R Jude RJ Nakamura Takashi T Soballe Kjeld K O'Keefe Regis J RJ Boyce Brendan F BF Schwarz Edward M EM

Nature medicine 20050213 3

Structural allograft healing is limited because of a lack of vascularization and remodeling. To study this we developed a mouse model that recapitulates the clinical aspects of live autograft and processed allograft healing. Gene expression analyses showed that there is a substantial decrease in the genes encoding RANKL and VEGF during allograft healing. Loss-of-function studies showed that both factors are required for autograft healing. To determine whether addition of these signals could stim ...[more]

PMID: 15711561

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