Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Richard Young
PROVIDER: E-GEOD-22556 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Kagey Michael H MH Newman Jamie J JJ Bilodeau Steve S Zhan Ye Y Orlando David A DA van Berkum Nynke L NL Ebmeier Christopher C CC Goossens Jesse J Rahl Peter B PB Levine Stuart S SS Taatjes Dylan J DJ Dekker Job J Young Richard A RA
Nature 20100818 7314
Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound transcription factors and the transcription apparatus at the core promoter, but this process is not well understood. Here we report that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells. Mediat ...[more]