Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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ChIP-chip from DmD8 cells with Twist antibodies after 30 minutes Notch activation


ABSTRACT: The transcription factor Twist is a critical cooperating factor that confers transcriptional specificity to the Notch pathway in muscle progenitor cells (DmD8) ChIP analysis of Twi show that Twist binding is significantly enriched in Notch responsive region in DmD8 cells 3 replicates of Twist ChIP after30 min. Notch activation.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Sarah Bray 

PROVIDER: E-GEOD-22650 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Specificity of Notch pathway activation: twist controls the transcriptional output in adult muscle progenitors.

Bernard Fred F   Krejci Alena A   Housden Ben B   Adryan Boris B   Bray Sarah J SJ  

Development (Cambridge, England) 20100707 16


Cell-cell signalling mediated by Notch regulates many different developmental and physiological processes and is involved in a variety of human diseases. Activation of Notch impinges directly on gene expression through the Suppressor of Hairless [Su(H)] DNA-binding protein. A major question that remains to be elucidated is how the same Notch signalling pathway can result in different transcriptional responses depending on the cellular context and environment. Here, we have investigated the facto  ...[more]

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