Musashi 2 regulates normal hematopoiesis and accelerates leukemogenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Fatima Al-Shahrour
PROVIDER: E-GEOD-22778 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Kharas Michael G MG Lengner Christopher J CJ Al-Shahrour Fatima F Bullinger Lars L Ball Brian B Zaidi Samir S Morgan Kelly K Tam Winnie W Paktinat Mahnaz M Okabe Rachel R Gozo Maricel M Einhorn William W Lane Steven W SW Scholl Claudia C Fröhling Stefan S Fleming Mark M Ebert Benjamin L BL Gilliland D Gary DG Jaenisch Rudolf R Daley George Q GQ
Nature medicine 20100708 8
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to reduced engraftment and depletion of HSCs in vivo. Overexpression of human MSI2 in a mouse model increases HSC cell cycle progression and cooperates with the chronic myeloid leukemia-associated BCR-ABL ...[more]
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